PolysacDB Lipopolysaccharide 1257

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:03, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Campylobacter jejuni serotype O:41 strains

Basic Structure

N/A

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Patients infected with Campylobacter jejuni serotype O:41 strains

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab SM1-8

Antibody type and class

IgM

Assay System

Immunoblotting

Cross-reactivity

This antibody was specifc to O:41 strains and did not cross-react with any of the other Campylobacter jejuni strains. Also cross-reacted with human GM1 ganglioside

Proposed epitopes

This Mab binds the terminal dissacharide Galβ1-->3GalNAc in the presence of laterally attached N-acetylneuraminic acid [Neu5Ac]

Proposed Utility

This Mab will help in the unveiling of the mechanisms of molecular mimicry exhibited by campylobacter LPS with human ganglioside and its functional significance in the disease progression

Weblink

PubMed Central

External Links

• Link to PolysacDB database