PolysacDB Lipopolysaccharide 1257

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Campylobacter jejuni serotype O:41 strains

[edit] Basic Structure

N/A

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Patients infected with Campylobacter jejuni serotype O:41 strains

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab SM1-8

[edit] Antibody type and class

IgM

[edit] Assay System

Immunoblotting

[edit] Cross-reactivity

This antibody was specifc to O:41 strains and did not cross-react with any of the other Campylobacter jejuni strains. Also cross-reacted with human GM1 ganglioside

[edit] Proposed epitopes

This Mab binds the terminal dissacharide Galβ1-->3GalNAc in the presence of laterally attached N-acetylneuraminic acid [Neu5Ac]

[edit] Proposed Utility

This Mab will help in the unveiling of the mechanisms of molecular mimicry exhibited by campylobacter LPS with human ganglioside and its functional significance in the disease progression

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database