Narcein
From DrugPedia: A Wikipedia for Drug discovery
(→External Links) |
|||
| Line 87: | Line 87: | ||
[http://crdd.osdd.net/raghava/biadb/detail.php?id=2121 Link to BIAdb Database] | [http://crdd.osdd.net/raghava/biadb/detail.php?id=2121 Link to BIAdb Database] | ||
| + | [[Category:BIAdb]] | ||
==References== | ==References== | ||
Harborne,Phytochemical Dictionary Second Edition,Taylor and Francis,(1999),Chapter21 | Harborne,Phytochemical Dictionary Second Edition,Taylor and Francis,(1999),Chapter21 | ||
Revision as of 11:07, 10 December 2009
| Narcein
| |
| Systematic (IUPAC) name | |
| 6-[2-[6-(2-dimethylaminoethyl)-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxybenzoic acid | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | |
| ChemSpider | |
| Chemical data | |
| Formula | C23H27NO8 |
| Mol. mass | 445.46238 |
| SMILES | & |
| Physical data | |
| Melt. point | 138 °C |
| Solubility in water | 780 mg/mL |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Contents |
Description
Narcein crystalize in long white prisms or neeedles, inodorous, having a bitter taste, soluble in alcohol, slightly so in chloroform and carbon disulphide, hardly soluble in banzene and in ether.
Source
Papaver rhopalothece
Papaver somniferum
General Properties
*Molecular Weight
445.46238
*Molecular Formula
C23H27NO8
*IUPAC NAME
6-[2-[6-(2-dimethylaminoethyl)-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxybenzoic acid
*Canonical Smiles
CN(C)CCC1=CC2=C(C(=C1CC(=O)C3=C(C(=C(C=C3)OC)OC)C(=O)O)OC)OCO2
*Isomeric Smiles
N/A
*XLogP
2.1
*Topological Polar Surface Area
104
Function
antitussive like codeine, but with no analgesic activity
lower blood pressure
stimulate intestinal peristalsis
stimulate respiration
Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD, MUSCLE WEAKNESS, MUSCLE CONTRACTION OR SPASTICITY) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 233, Pg. 550, 1958.
dog LDLo intravenous 2200mg/kg (2200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD, MUSCLE WEAKNESS, MUSCLE CONTRACTION OR SPASTICITY) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 233, Pg. 550, 1958.
mouse LD50 intravenous 2gm/kg (2000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD, MUSCLE WEAKNESS, MUSCLE CONTRACTION OR SPASTICITY) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 233, Pg. 550, 1958.
mouse LDLo subcutaneous 100mg/kg (100mg/kg) BEHAVIORAL: EXCITEMENT "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933.
rabbit LDLo intravenous 1800mg/kg (1800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD, MUSCLE WEAKNESS, MUSCLE CONTRACTION OR SPASTICITY) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 233, Pg. 550, 1958.
External Links
References
Harborne,Phytochemical Dictionary Second Edition,Taylor and Francis,(1999),Chapter21
