Narcein
From DrugPedia: A Wikipedia for Drug discovery
| Narcein
| |
| Systematic (IUPAC) name | |
| 6-[2-[6-(2-dimethylaminoethyl)-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxybenzoic acid | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | |
| ChemSpider | |
| Chemical data | |
| Formula | C23H27NO8 |
| Mol. mass | 445.46238 |
| SMILES | & |
| Physical data | |
| Melt. point | 138 °C |
| Solubility in water | 780 mg/mL |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Contents |
[edit] Description
Narcein crystalize in long white prisms or neeedles, inodorous, having a bitter taste, soluble in alcohol, slightly so in chloroform and carbon disulphide, hardly soluble in banzene and in ether.
[edit] Source
Papaver rhopalothece
Papaver somniferum
[edit] General Properties
*Molecular Weight
445.46238
*Molecular Formula
C23H27NO8
*IUPAC NAME
6-[2-[6-(2-dimethylaminoethyl)-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxybenzoic acid
*Canonical Smiles
CN(C)CCC1=CC2=C(C(=C1CC(=O)C3=C(C(=C(C=C3)OC)OC)C(=O)O)OC)OCO2
*Isomeric Smiles
N/A
*XLogP
2.1
*Topological Polar Surface Area
104
[edit] Function
antitussive like codeine, but with no analgesic activity
lower blood pressure
stimulate intestinal peristalsis
stimulate respiration
[edit] Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 800mg/kg (800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD, MUSCLE WEAKNESS, MUSCLE CONTRACTION OR SPASTICITY) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 233, Pg. 550, 1958.
dog LDLo intravenous 2200mg/kg (2200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD, MUSCLE WEAKNESS, MUSCLE CONTRACTION OR SPASTICITY) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 233, Pg. 550, 1958.
mouse LD50 intravenous 2gm/kg (2000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD, MUSCLE WEAKNESS, MUSCLE CONTRACTION OR SPASTICITY) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 233, Pg. 550, 1958.
mouse LDLo subcutaneous 100mg/kg (100mg/kg) BEHAVIORAL: EXCITEMENT "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933.
rabbit LDLo intravenous 1800mg/kg (1800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD, MUSCLE WEAKNESS, MUSCLE CONTRACTION OR SPASTICITY) Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 233, Pg. 550, 1958.
[edit] External Links
[edit] References
Harborne,Phytochemical Dictionary Second Edition,Taylor and Francis,(1999),Chapter21
