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Revision as of 08:12, 2 February 2010 (edit) Priyanka priyadarshini (Talk | contribs) (New page: {{immunebox | Name =<Rv3608c> dihydropteroate synthase |image= | width=250 |image2= |Swiss Prot = P0A578 | Genbank = | PDB = 1EYE | DrugBank = | chem...) ← Previous diff		Revision as of 08:18, 2 February 2010 (edit) (undo) Priyanka priyadarshini (Talk | contribs) Next diff →
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	SALAALHGAWGVRVHDVRASVDAIKVVEAWMGAERIERDG		SALAALHGAWGVRVHDVRASVDAIKVVEAWMGAERIERDG
	*		*
		+	=Human Homologue Blast Result=
		+
		+	<table border='1'><tr>
		+
		+	<td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr>
		+
		+	<tr><td> sp|Q8IWV2</td><td> 37</td><td> 52</td><td> 51</td><td> 2.4</td></tr>
		+
		+	<tr><td> sp|Q5T9C9</td><td> 40</td><td> 62</td><td> 35</td><td> 5.9</td></tr>
		+
		+	<tr><td>sp|Q8N3K9</td><td> 22</td><td> 39</td><td> 117</td><td> 7.0</td></tr>
		+
		+	<tr><td>sp|Q86XD8</td><td> 40</td><td> 60</td><td> 25</td><td> 9.2</td></tr>
		+
		+	<tr><td> sp|P52732</td><td> 28</td><td> 45</td><td> 66</td><td> 9.9</td></tr></table>

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Revision as of 08:18, 2 February 2010

Immunotation of Rv3608C
Name
<Rv3608c> dihydropteroate synthase
Identifiers
Swiss Prot	P0A578
Genbank	?
PDB	1EYE
Chemical data
Formula	?
Mol. wt.	28842.7
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	4.94

General

Rv3608c, (MTCY07H7B.14), folP, len: 280. Dihydropteroate synthase, similar to e.g. DHPS_ECOLI P26282 dihydropteroate synthase (ec 2.5.1.15 SECOND STEP IN DIHYDROFOLATE BIOSYNTHESIS(282 aa), fasta scores, opt:642, E(): 0, (42.0%identity in 274 aa overlap); contains PS00792 Dihydropteroate synthase signature 1, PS00793 Dihydropteroate synthase signature 2. Updated info: Functional Category: intermediary metabolism and respiration. EC:2.5.1.15 Dihydropteroate synthetase is an enzyme classified under EC 2.5.1.15. It produces dihydropteroate in bacteria, but does not function in humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.

It acts upon 4-Aminobenzoic acid (PABA} and dihydropteridine-hydroxymethyl-pyrophosphate.

Protein Sequence

>Rv3608c, TB.seq 4049138:4049977 MW:28812 VSPAPVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAGIVDVGGESSRPGATRVDPAVETSRVIPVVKELAAQG ITVSIDTMRADVARAALQNGAQMVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSADTPHVPVRYGNVVAEVRADLLAS VADAVAAGVDPARLVLDPGLGFAKTAQHNWAILHALPELVATGIPVLVGASRKRFLGALLAGPDGVMRPTDGRDTATAVI SALAALHGAWGVRVHDVRASVDAIKVVEAWMGAERIERDG

Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q8IWV2	37	52	51	2.4
sp|Q5T9C9	40	62	35	5.9
sp|Q8N3K9	22	39	117	7.0
sp|Q86XD8	40	60	25	9.2
sp|P52732	28	45	66	9.9