18-hydroxycorticosterone
From DrugPedia: A Wikipedia for Drug discovery
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| + | {{Drugbox | ||
| + | | IUPAC_name = (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | ||
| + | | CAS_number = 561-65-9 | ||
| + | | CAS_supplemental = | ||
| + | | ATC_suffix = BA03 | ||
| + | | ATC_supplemental = | ||
| + | | PubChem = 11222 | ||
| + | | ChemSpiderID = | ||
| + | | chemical_formula =C<sub>2</sub><sub>1</sub>H<sub>3</sub><sub>0</sub>O<sub>5</sub> | ||
| + | | molecular_weight = 362.46 | ||
| + | | smiles = CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)CO)O | ||
| + | | synonyms = 11beta,18,21-Trihydroxypregn-4-ene-3,20-dione | ||
| + | | density = | ||
| + | | melting_point = | ||
| + | | boiling_point = | ||
| + | | solubility = | ||
| + | | specific_rotation = | ||
| + | | sec_combustion = | ||
| + | | bioavailability = | ||
| + | | protein_bound = | ||
| + | | metabolism = | ||
| + | | elimination_half-life = | ||
| + | | excretion = | ||
| + | | pregnancy_category= | ||
| + | | dependency_liability = | ||
| + | | routes_of_administration = | ||
| + | }} | ||
| + | [http://172.141.127.22/raghava/hmrbase/test_extract.php?db=arun&table=nphormonet&id=1007&show=SHOW-3D Show 3-D Structure] | ||
==Description== | ==Description== | ||
| - | + | '''18-Hydroxycorticosterone''' is a derivative of [[corticosterone]]. | |
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| + | It serves as an intermediate in the synthesis of [[aldosterone]] by the enzyme [[aldosterone synthase]] in the [[zona glomerulosa]]: | ||
| + | |||
==General Properties== | ==General Properties== | ||
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C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO)O | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO)O | ||
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| - | [[ | + | [[Category:Hormones]] |
| + | [[Category:Corticosteroids]] | ||
Current revision
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| 18-hydroxycorticosterone
| |
| Systematic (IUPAC) name | |
| (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C21H30O5 |
| Mol. mass | 362.46 |
| SMILES | & |
| Synonyms | 11beta,18,21-Trihydroxypregn-4-ene-3,20-dione |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
[edit] Description
18-Hydroxycorticosterone is a derivative of corticosterone.
It serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa:
[edit] General Properties
*Molecular Weight
362.46
*Molecular Formula
C21H30O5
*IUPAC NAME
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
*Canonical Smiles
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)CO)O
*Isomeric Smiles
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO)O
