Immunotation of Rv3874

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(New page: {{immunebox | Name =<b> M. tuberculosis-specific antigen 10</b> |image= | width=250 |image2= |Swiss Prot = P0A566 | Genbank = 886194 | PDB = | DrugBank ...)
Current revision (12:03, 23 February 2010) (edit) (undo)
(IEDB Analysis)
 
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=Human Homologue Blast Result=
=Human Homologue Blast Result=
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<table border='1'><tr>
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no significant similarity found
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<td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr>
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<tr><td></td><td> </td><td> </td><td> </td><td> </td></tr></table>
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=Alergen Protein=
=Alergen Protein=
Link to [http://www.imtech.res.in/raghava/algpred/ Algpred]<br>
Link to [http://www.imtech.res.in/raghava/algpred/ Algpred]<br>
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Non Allergen Predicted by AlgPred Server
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Allergen Predicted by AlgPred Server
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=Bacterial Toxin Prediction=
=Bacterial Toxin Prediction=
Link to [http://www.imtech.res.in/raghava/btxpred/submission.html btxpred]<br>
Link to [http://www.imtech.res.in/raghava/btxpred/submission.html btxpred]<br>
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No Hit Fountd by btxpred server.
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one Hit Fountd by btxpred server.
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"PSI-BLAST Result of exotoxin functions --- 
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Neurotoxin"as predicted by btxpred server.
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=Subcellular Location=
=Subcellular Location=
Link to [http://www.imtech.res.in/raghava/tbpred/ TBpred]<br>
Link to [http://www.imtech.res.in/raghava/tbpred/ TBpred]<br>
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Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred]   
Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred]   
<br>
<br>
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Result Predicited by  []<br>
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Result Predicited by  [http://crdd.osdd.net/drugpedia/images/1231231.pdf]<br>
====ABCpred Analysis====
====ABCpred Analysis====
Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br>
Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br>
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Result Predicited by  []<br>
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Result Predicited by  [http://crdd.osdd.net/drugpedia/images/1231232.pdf]<br>
====IEDB Analysis====
====IEDB Analysis====
Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br>
Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br>
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Result Predicited by  []<br>
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Result Predicited by  [http://crdd.osdd.net/drugpedia/images/1231233.pdf]<br>
=MHC Class-I Binder=
=MHC Class-I Binder=
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Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred]
Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred]
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<br>  
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Result Predicited by  []<br>
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Result Predicited by  [http://crdd.osdd.net/drugpedia/images/00001.pdf]<br>
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==IEDB Analysis==
==IEDB Analysis==
Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br>
Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br>
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Result Predicted by []
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Result Predicted by [http://crdd.osdd.net/drugpedia/images/Ami2.txt]
=MHC Class-II Binder=
=MHC Class-II Binder=
==Propred Analysis==
==Propred Analysis==
Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br>
Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br>
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Result Predicted by []
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Result Predicted by [http://crdd.osdd.net/drugpedia/images/Ami1.pdf]
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==NetMHC-II Analysis==
==NetMHC-II Analysis==

Current revision

Immunotation of Rv3874
Name
M. tuberculosis-specific antigen 10
Identifiers
Swiss Prot P0A566
Genbank 886194
PDB  ?
Chemical data
Formula [1]
Mol. wt. 10794 Da
Pharmacokinetic data
Bioavailability  ?
Solubility  ?
Isoelectric-Point  ?

Contents

[edit] General

In a search for new skin test reagents specific for tuberculosis, it has been found that the antigen encoded by gene Rv3874 of Mycobacterium tuberculosis elicited delayed-type hypersensitivity in M. tuberculosis-infected guinea pigs but not in control animals immunized with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or Mycobacterium avium. The antigen, which was named MTSA-10 (for M. tuberculosis-specific antigen 10), is a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test of latent M. tuberculosis infection from vaccination with BCG or from sensitization with environmental, nontuberculous mycobacteria.


[edit] Protein Sequence

>Rv3874, TB.seq 4352271:4352570 MW:10794 MAEMKTDAATLAQEAGNFERISGDLKTQIDQVESTAGSLQGQWRGAAGTAAQAAVVRFQEAANKQKQELDEISTNIRQAG VQYSRADEEQQQALSSQMGF


[edit] Human Homologue Blast Result

no significant similarity found

[edit] Alergen Protein

Link to Algpred
Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
one Hit Fountd by btxpred server. "PSI-BLAST Result of exotoxin functions --- Neurotoxin"as predicted by btxpred server.

[edit] Subcellular Location

Link to TBpred
Cyoplasmic

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [7]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by []

[edit] External Links

  • Database of Mycobacterium tuberculosis genome sequences and related information.