Immunotation of Rv3874
From DrugPedia: A Wikipedia for Drug discovery
| Immunotation of Rv3874
| |
| Name | |
| M. tuberculosis-specific antigen 10 | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | ? |
| Chemical data | |
| Formula | [1] |
| Mol. wt. | 10794 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | ? |
Contents |
[edit] General
In a search for new skin test reagents specific for tuberculosis, it has been found that the antigen encoded by gene Rv3874 of Mycobacterium tuberculosis elicited delayed-type hypersensitivity in M. tuberculosis-infected guinea pigs but not in control animals immunized with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or Mycobacterium avium. The antigen, which was named MTSA-10 (for M. tuberculosis-specific antigen 10), is a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test of latent M. tuberculosis infection from vaccination with BCG or from sensitization with environmental, nontuberculous mycobacteria.
[edit] Protein Sequence
>Rv3874, TB.seq 4352271:4352570 MW:10794 MAEMKTDAATLAQEAGNFERISGDLKTQIDQVESTAGSLQGQWRGAAGTAAQAAVVRFQEAANKQKQELDEISTNIRQAG VQYSRADEEQQQALSSQMGF
[edit] Human Homologue Blast Result
no significant similarity found
[edit] Alergen Protein
Link to Algpred
Allergen Predicted by AlgPred Server
[edit] Bacterial Toxin Prediction
Link to btxpred
one Hit Fountd by btxpred server.
"PSI-BLAST Result of exotoxin functions ---
Neurotoxin"as predicted by btxpred server.
[edit] Subcellular Location
Link to TBpred
Cyoplasmic
[edit] Antigens
No Hit Found in AntigenDB
No. Hit Found in IEDB
[edit] B cell Epitopes
[edit] BCEpred Analysis
Link to Bcepred
Result Predicited by [2]
[edit] ABCpred Analysis
Link to ABCpred
Result Predicited by [3]
[edit] IEDB Analysis
Link to IEDB
Result Predicited by [4]
[edit] MHC Class-I Binder
[edit] nHLAPred Analysis
Link to nHLApred
Result Predicited by [5]
[edit] IEDB Analysis
Link to IEDB
Result Predicted by [6]
[edit] MHC Class-II Binder
[edit] Propred Analysis
Link to Propred
Result Predicted by [7]
[edit] NetMHC-II Analysis
Link to NetMHC-II
Result Predicted by []
[edit] External Links
- Database of Mycobacterium tuberculosis genome sequences and related information.
