Corticosterone

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[http://crdd.osdd.net/raghava/hmrbase/test_extract.php?db=arun&table=nphormonet&id=1032&show=SHOW-3D Show 3-D Structure]
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{{Drugbox
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'''CORTICOSTERONE'''
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| IUPAC_name        = (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
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Pubchem(5753)
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| CAS_number        = 50-22-6
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| CAS_supplemental  =
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| ATC_suffix =
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| ATC_supplemental  =
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| PubChem          = 5753
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| ChemSpiderID      =
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| chemical_formula  =C<sub>21</sub>H<sub>30</sub>O<sub>4</sub>
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| molecular_weight  = 346.46
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| smiles            =CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
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| synonyms          = 17-Deoxycortisol
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| density          =
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| melting_point    = 181
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| boiling_point    =
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| solubility        = 199 mg/L at 25<sup>o</sup>C EXP
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| specific_rotation =
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| sec_combustion    =
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| bioavailability  =
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| protein_bound    =
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| metabolism        =
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| elimination_half-life =
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| excretion        =
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| pregnancy_category=
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| dependency_liability =
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| routes_of_administration =
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}}
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437).Corticosterone is a 21 carbon [[steroid hormone]] of the [[corticosteroid]] type produced in the cortex of the [[adrenal gland]]s.  
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437).Corticosterone is a 21 carbon [[steroid hormone]] of the [[corticosteroid]] type produced in the cortex of the [[adrenal gland]]s.  
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==Physiochemical Properties==
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'''KEGG Pathway'''(C02140)
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===Melting Point===
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*C21-Steroid hormone metabolism
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181 deg C EXP
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{| border="1;width:100%; height:200px;style=text-align:center"
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===log P===
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|+'''List of PDB files having Corticosterone as a Ligand:'''
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1.94
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|-
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===Water Solubility====
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! style="background:brown; color:white" |MMDB ID
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199 mg/L 25 EXP
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! style="background:brown; color:white" |PDB ID
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Vapor Pressure===
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! style="background:brown; color:white" |Reference
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4.74E-12 mm Hg 25 EST
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|-
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Henry's Law Constant===
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|33346
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3.70E-10 atm-m3/mole 25 EST
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|1Y5R
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|Atmospheric OH Rate Constant===
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|Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957
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1.16E-10 cm3/molecule-sec 25 EST
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{| border="1;width:100%; height:200px;style=text-align:center"
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|+'''Physiochemical properties of Corticosterone:'''
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|-
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! style="background:brown; color:white" |Physical Property
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! style="background:brown; color:white" |Value
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! style="background:brown; color:white" |Units
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! style="background:brown; color:white" |Temp (deg C)
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! style="background:brown; color:white" |Source
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|Melting Point
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|181
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|deg C
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|  
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|EXP
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|-
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|log P (octanol-water)
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|1.94
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|(none)
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|  
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|EXP
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|Water Solubility
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|199
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|mg/L
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|25
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|EXP
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|-
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|Vapor Pressure
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|4.74E-12
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|mm Hg
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|25
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|EST
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|-
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|Henry's Law Constant
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|3.70E-10
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|atm-m3/mole
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|25
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|EST
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|-
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|Atmospheric OH Rate Constant
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|1.16E-10
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|cm3/molecule-sec
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|25
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|EST
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==Functions==
==Functions==
In many species, including [[rodent]]s, corticosterone is the principal [[glucocorticoid]], involved in regulation of fuel [[metabolism]], [[immune]] reactions, and [[stress (medicine)|stress]] responses.
In many species, including [[rodent]]s, corticosterone is the principal [[glucocorticoid]], involved in regulation of fuel [[metabolism]], [[immune]] reactions, and [[stress (medicine)|stress]] responses.
However, in [[humans]], corticosterone is produced primarily in the [[zona fasciculata]] of the [[adrenal cortex]]. It has only weak [[glucocorticoid]] and [[mineralocorticoid]] potencies in humans and is important mainly as an intermediate in the [[steroidogenic pathway]] from [[pregnenolone]] to [[aldosterone]].  Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells.  Glomerulosa cells are found in the [[Zona glomerulosa]], which is the most superficial region of endocrine cells in the [[adrenal cortex]].
However, in [[humans]], corticosterone is produced primarily in the [[zona fasciculata]] of the [[adrenal cortex]]. It has only weak [[glucocorticoid]] and [[mineralocorticoid]] potencies in humans and is important mainly as an intermediate in the [[steroidogenic pathway]] from [[pregnenolone]] to [[aldosterone]].  Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells.  Glomerulosa cells are found in the [[Zona glomerulosa]], which is the most superficial region of endocrine cells in the [[adrenal cortex]].

Revision as of 06:58, 20 February 2009

Show 3-D Structure

Corticosterone
Systematic (IUPAC) name
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number 50-22-6
ATC code  ?
PubChem 5753
Chemical data
Formula C21H30O4
Mol. mass 346.46
SMILES eMolecules & PubChem
Synonyms 17-Deoxycortisol
Physical data
Melt. point 181 °C
Solubility in water 199 mg/L at 25oC EXP mg/mL
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437).Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.

Contents

Physiochemical Properties

Melting Point

181 deg C EXP

log P

1.94

Water Solubility=

199 mg/L 25 EXP Vapor Pressure=== 4.74E-12 mm Hg 25 EST Henry's Law Constant=== 3.70E-10 atm-m3/mole 25 EST |Atmospheric OH Rate Constant=== 1.16E-10 cm3/molecule-sec 25 EST

Functions

In many species, including rodents, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.

However, in humans, corticosterone is produced primarily in the zona fasciculata of the adrenal cortex. It has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells. Glomerulosa cells are found in the Zona glomerulosa, which is the most superficial region of endocrine cells in the adrenal cortex.

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