Hydrocortisone

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Revision as of 07:12, 13 February 2009

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

Description

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

General Properties

*Molecular Weight

362.46

*Molecular Formula

C₂₁H₃₀O₅

*IUPAC NAME

(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

*Canonical Smiles

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O

*Isomeric Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O

PhysioChemical Properties

*Melting Point

220(EXP)

*LogP

1.61(EXP)

*Water Solubility

320(EXP) at 25C

External Links

• [1]Pubchem
• [2]]2Q1V,[[3]]2V95,[[4]]2VDY,
• [5]KEGG Compound
• [6]KEGG Drug
• [7]Human Metabolome DataBase
• [8]Drugbank

Categories:Hormones