Hydrocortisone

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

[edit] Description

Show 3-D Structure

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

[edit] General Properties

*Molecular Weight

362.46

*Molecular Formula

C₂₁H₃₀O₅

*IUPAC NAME

(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

*Canonical Smiles

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O

*Isomeric Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O

[edit] PhysioChemical Properties

*Melting Point

220(EXP)

*LogP

1.61(EXP)

*Water Solubility

320(EXP) at 25C

[edit] External Links

• [1]Pubchem
• [2]]2Q1V,[[3]]2V95,[[4]]2VDY,
• [5]KEGG Compound
• [6]KEGG Drug
• [7]Human Metabolome DataBase
• [8]Drugbank