Acetylcholine
From DrugPedia: A Wikipedia for Drug discovery
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* cardiovascular agent | * cardiovascular agent | ||
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'''KEGG Pathway'''(C01996) | '''KEGG Pathway'''(C01996) | ||
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*Neuroactive ligand-receptor interaction | *Neuroactive ligand-receptor interaction | ||
*Regulation of actin cytoskeleton | *Regulation of actin cytoskeleton | ||
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| - | + | |+'''List of PDB files having estriol as a Ligand:''' | |
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| + | ! style="background:brown; color:white" |MMDB ID | ||
| + | ! style="background:brown; color:white" |PDB ID | ||
| + | ! style="background:brown; color:white" |Reference | ||
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|40549 | |40549 | ||
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|Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 88, 1971. | |Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 88, 1971. | ||
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|mouse | |mouse | ||
|LD50 | |LD50 | ||
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|intraperitoneal | |intraperitoneal | ||
|250mg/kg (250mg/kg) | |250mg/kg (250mg/kg) | ||
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|BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 171, 1944. | |BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 171, 1944. | ||
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|subcutaneous | |subcutaneous | ||
|250mg/kg (250mg/kg) | |250mg/kg (250mg/kg) | ||
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|"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 29, 1973. | |"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 29, 1973. | ||
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Current revision
Acetylcholine Pubchem(187)
A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.
Therapeutic Uses
- vasodilator
- cardiovascular agent
Drug Type: Small Molecule; Experimental
KEGG Pathway(C01996)
- Glycerophospholipid metabolism
- Neuroactive ligand-receptor interaction
- Regulation of actin cytoskeleton
| MMDB ID | PDB ID | Reference |
|---|---|---|
| 40549 | 2HA4 | Bourne Y, Radic Z, Sulzenbacher G, Kim E, Taylor P, Marchot PSubstrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium bindingJ. Biol. Chem. v281, p.29256-29267 |
| 43955 | 2J0H | Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud CStructural insights into the innate immune recognition specificities of L- and H-ficolinsEMBO J. v26, p.623-633 |
| 66998 | 2RIN | Oswald C, Smits SH, Hoing M, Sohn-Bosser L, Dupont L, Le Rudulier D, Schmitt L, Bremer ECrystal structures of the choline/acetylcholine substrate binding protein ChoX from Sinorhizobium meliloti in the liganded and unliganded closed statesJ. Biol. Chem. v, p. |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 170mg/kg (170mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 88, 1971. | |
| mouse | LD50 | intravenous | 11mg/kg (11mg/kg) | Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972. | |
| rabbit | LD50 | intravenous | 300ug/kg (0.3mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 39, 1973. | |
| rat | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 171, 1944. | |
| rat | LD50 | subcutaneous | 250mg/kg (250mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 29, 1973. |
