Corticosterone

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(New page: CORTICOSTERONE Pubchem(5753) An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacologic...)
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CORTICOSTERONE
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'''CORTICOSTERONE'''
Pubchem(5753)
Pubchem(5753)
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
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KEGG Pathway(C02140)
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'''KEGG Pathway'''(C02140)
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C21-Steroid hormone metabolism
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*C21-Steroid hormone metabolism
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MMDB ID: 33346
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|33346
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PDB ID: 1Y5R
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|1Y5R
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Reference: Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957
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|Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957
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11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of 11-dehydrocorticosterone to its active form corticosterone in rodents (or cortisone to cortisol in humans). The reductive reaction of the 11-keto to 11-hydroxyl is the pivotal switch in the activation of glucocorticoids. An excess of active glucocorticoids has been shown to play a key role in metabolic disorders such as diabetes and obesity....
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Physical Property  Value  Units  Temp (deg C)  Source
Physical Property  Value  Units  Temp (deg C)  Source
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Melting Point 181 deg C   EXP
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|Melting Point
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log P (octanol-water) 1.94 (none)   EXP
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|181
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Water Solubility 199 mg/L 25 EXP
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|deg C
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Vapor Pressure 4.74E-12 mm Hg 25 EST
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|  
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Henry's Law Constant 3.70E-10 atm-m3/mole 25 EST
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|EXP
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Atmospheric OH Rate Constant 1.16E-10 cm3/molecule-sec 25
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|-
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|log P (octanol-water)
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|1.94
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|(none)  
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|EXP
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|-
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|Water Solubility
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|199
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|mg/L
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|25
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|EXP
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|-
 +
|Vapor Pressure
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|4.74E-12
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|mm Hg 25
 +
|EST
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|-
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|Henry's Law Constant
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|3.70E-10
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|atm-m3/mole
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|25
 +
|EST
 +
|-
 +
|Atmospheric OH Rate Constant
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|1.16E-10
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|cm3/molecule-sec
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|25
 +
|-
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|}

Revision as of 08:28, 30 October 2008

CORTICOSTERONE Pubchem(5753)

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

KEGG Pathway(C02140)

  • C21-Steroid hormone metabolism

|33346 |1Y5R |Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957

Physical Property Value Units Temp (deg C) Source |Melting Point |181 |deg C | |EXP |- |log P (octanol-water) |1.94 |(none) |EXP |- |Water Solubility |199 |mg/L |25 |EXP |- |Vapor Pressure |4.74E-12 |mm Hg 25 |EST |- |Henry's Law Constant |3.70E-10 |atm-m3/mole |25 |EST |- |Atmospheric OH Rate Constant |1.16E-10 |cm3/molecule-sec |25 |- |}

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