Corticosterone

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		+	CORTICOSTERONE
		+	Pubchem(5753)
		+	An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
-	<table align='right' border=1>	+	KEGG Pathway(C02140)
-	<tr><td>	+	C21-Steroid hormone metabolism
-	<jmol><jmolApplet>	+
-	<size>200</size>	+
-	<script>spin on;color atoms amino;</script>	+
-	<uploadedFileContents>NPH132.SDF</uploadedFileContents>	+
-	<color>black</color>	+
-	</jmolApplet>	+
-	</jmol>	+
-	</td></tr></table>	+
-	==Description==	+
-	An adrenocortical steroid that has modest but significant activities  as a mineralocorticoid and a glucocorticoid. (From Goodman and  Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)	+
-	==General Properties==	+
-	<b>*Molecular Weight</b>	+	MMDB ID: 33346
		+	PDB ID: 1Y5R
		+	Reference: Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957
		+	11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of 11-dehydrocorticosterone to its active form corticosterone in rodents (or cortisone to cortisol in humans). The reductive reaction of the 11-keto to 11-hydroxyl is the pivotal switch in the activation of glucocorticoids. An excess of active glucocorticoids has been shown to play a key role in metabolic disorders such as diabetes and obesity....
-	346.46	+	Physical Property  Value  Units  Temp (deg C) Source
-		+	Melting Point 181 deg C   EXP
-	<b>*Molecular Formula</b>	+	log P (octanol-water) 1.94 (none)   EXP
-		+	Water Solubility 199 mg/L 25 EXP
-	C<sub>2</sub><sub>1</sub>H<sub>3</sub><sub>0</sub>O<sub>4</sub>	+	Vapor Pressure 4.74E-12 mm Hg 25 EST
-		+	Henry's Law Constant 3.70E-10 atm-m3/mole 25 EST
-	<b>*IUPAC NAME</b>	+	Atmospheric OH Rate Constant 1.16E-10 cm3/molecule-sec 25
-		+
-	(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one	+
-		+
-	<b>*Canonical Smiles</b>	+
-		+
-	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O	+
-		+
-	<b>*Isomeric Smiles</b>	+
-		+
-	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O	+
-		+
-		+
-	==PhysioChemical Properties==	+
-		+
-	<b>*Melting Point</b>	+
-		+
-	181(EXP)	+
-		+
-	<b>*LogP</b>	+
-		+
-	1.94(EXP)	+
-		+
-	<b>*Water Solubility</b>	+
-		+
-	199(EXP) at 25C	+
-		+
-	==External Links==	+
-	*[http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5753]Pubchem	+
-	*[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1Y5R]]1Y5R,	+
-	*[http://www.genome.jp/dbget-bin/www_bget?compound+C02140]]KEGG Compound	+
-	*[http://www.hmdb.ca/metabolites/HMDB01547]Human Metabolome DataBase	+
-		+
-		+
-	[[Categories:Hormones]]	+

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Revision as of 08:25, 30 October 2008

CORTICOSTERONE Pubchem(5753)

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

KEGG Pathway(C02140) C21-Steroid hormone metabolism

MMDB ID: 33346 PDB ID: 1Y5R Reference: Zhang J, Osslund TD, Plant MH, Clogston CL, Nybo RE, Xiong F, Delaney JM, Jordan SRCrystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetesBiochemistry v44, p.6948-6957 11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of 11-dehydrocorticosterone to its active form corticosterone in rodents (or cortisone to cortisol in humans). The reductive reaction of the 11-keto to 11-hydroxyl is the pivotal switch in the activation of glucocorticoids. An excess of active glucocorticoids has been shown to play a key role in metabolic disorders such as diabetes and obesity....

Physical Property Value Units Temp (deg C) Source Melting Point 181 deg C EXP log P (octanol-water) 1.94 (none) EXP Water Solubility 199 mg/L 25 EXP Vapor Pressure 4.74E-12 mm Hg 25 EST Henry's Law Constant 3.70E-10 atm-m3/mole 25 EST Atmospheric OH Rate Constant 1.16E-10 cm3/molecule-sec 25