Rv0350
From DrugPedia: A Wikipedia for Drug discovery
(New page: {{immunebox | Name =<b> molecular chaperone DnaK </b> |image= | width=250 |image2= |Swiss Prot = P0A5B9 | Genbank = 885946 | PDB = 3FIG, 1SR9 | DrugBank ...) |
|||
| Line 6: | Line 6: | ||
|Swiss Prot = P0A5B9 | |Swiss Prot = P0A5B9 | ||
| Genbank = 885946 | | Genbank = 885946 | ||
| - | | PDB = | + | | PDB = |
| DrugBank = | | DrugBank = | ||
| chemical_formula = C18H21NO3 [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=885946&loc=ec_rcs] | | chemical_formula = C18H21NO3 [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=885946&loc=ec_rcs] | ||
Revision as of 18:36, 22 February 2010
| Rv0350
| |
| Name | |
| molecular chaperone DnaK | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | ? |
| Chemical data | |
| Formula | C18H21NO3 [1] |
| Mol. wt. | 66832 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 4.8 |
Contents |
General
ACTS AS A CHAPERONE. INVOLVED IN INDUCTION BY STRESS CONDITIONS e.g. HEAT SHOCK. POSSIBLY HAS AN ATPASE ACTIVITY. SEEMS TO BE REGULATED POSITIVELY BY SIGH (Rv3223c PRODUCT) AND NEGATIVELY BY HSPR (Rv0353 PRODUCT).
Conserved hypothetical proline rich protein
Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003)
Protein Sequence
>Rv0350, TB.seq 419833:421707 MW:66832 MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARNGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIE IDGKKYTAPEISARILMKLKRDAEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKG EKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGIDLTKDKMAMQRLREAAEK AKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMP AVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSETF TTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIVHVTAKDKGTGKENTIRIQEGSG LSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDI SAIKSAMEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREAK
Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|P38646.2 | 54 | 70 | 621 | 0.0 |
| sp|P11021.2 | 50 | 65 | 614 | 4e-163 |
| sp|P11142.1 | 51 | 67 | 558 | 6e-153 |
| sp|P17066.2 | 48 | 63 | 612 | 3e-151 |
| sp|P08107.5 | 50 | 67 | 559 | 1e-150 |
Alergen Protein
Link to Algpred
Non Allergen Predicted by AlgPred Server
Bacterial Toxin Prediction
Link to btxpred
No Hit Fountd by btxpred server.
Subcellular Location
Link to TBpred
Integral Membrane
Antigens
No Hit Found in AntigenDB
No. Hit Found in IEDB
B cell Epitopes
BCEpred Analysis
Link to Bcepred
Result Predicited by
ABCpred Analysis
Link to ABCpred
Result Predicited by
IEDB Analysis
Link to IEDB
Result Predicited by
MHC Class-I Binder
nHLAPred Analysis
Link to nHLApred
Result Predicited by nHLApred
IEDB Analysis
Link to IEDB
Result Predicted by IEDB
MHC Class-II Binder
Propred Analysis
Link to Propred
Result Predicted by
NetMHC-II Analysis
Link to NetMHC-II
Result Predicted by
External Links
- Database of Mycobacterium tuberculosis genome sequences and related information.
