Testicular receptor 2;mTR2

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Mus musculus (Mouse).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.

[edit] Subcellular Localization

Nucleus (Potential).

[edit] Developmental Stage

Isoform 1 is highly expressed in early to midgestation embryos, with expression leveling off during stage E15. After birth, expression in the testes remains at a basal level until puberty, begins to increase at postnatal day 16 and peaks at postnatal days 20 to 24. Expression is maintained at a high level throughout adulthood. Isoform 2 peaks transiently at postnatal day 24.

[edit] Similarity

Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.

[edit] Post translational Modification

[edit] Function

Orphan nuclear receptor. Isoform 1 represses transcription and binds DNA as a homodimer. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism.