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• Targeted Drug Delivery
  ... sful, the result of the targeting would be a significant reduction in drug toxicity, reduction of the drug dose, and increased treatment efficacy. All in all, ...
  4 KB (602 words) - 13:27, 5 November 2011
• Drug Discovery
  ... nt of resistance, transport mechanisms such as export pumps, side effects, toxicity, and others. * Cell-based assays range in their complexity from simple cytotoxicity assays or cell growth to reporter gene assays that monitor activation or u ...
  23 KB (3467 words) - 03:48, 1 September 2008
• Phase III
  ... safety profile, the occurrence of undesirable side-effects, and long-term toxicity.During this stage, the scientists are able to select the lead molecule tha ...
  360 B (52 words) - 08:51, 31 July 2008
• ADMET
  '''Drug toxicology''' refer to the study of chemical toxicity of the drug. ... systems can generate and validate accurate, rapid assessments of chemical toxicity solely from a chemical’s molecular structure.
  3 KB (515 words) - 12:01, 29 August 2008
• Lipinski's
  ... bstructures, e.g., those associated with problems in chemical stability or toxicity.
  558 B (80 words) - 07:15, 11 August 2008
• Toxicology
  ... study of fundamental mechanisms to the measurement of exposure, including toxicity testing and risk analysis, requires an extensively interdisciplinary appro ... Toxicity is a function of the effective dose (how much) of a foreign chemical ([[xe ...
  5 KB (751 words) - 08:13, 19 August 2008
• Pharmacology
  ... de several species to help in the evaluation of both the effectiveness and toxicity of the drug. The dosage of any drug approved for use is intended to fall w ...
  12 KB (1662 words) - 11:32, 20 August 2008
• Descriptive Toxicology
  A branch of [[Toxicology]], typically involves toxicity testing. '''Broad spectrum of responses reflects toxicity'''
  2 KB (221 words) - 10:03, 11 August 2008
• Regulatory Toxicology
  * Toxicity evidence is the basis, but often rules are modified by political, legal co ...
  871 B (108 words) - 10:08, 11 August 2008
• Chemical file format
  ... US Environmental Protection Agency's The Distributed Structure-Searchable Toxicity (DSSTox) Database Network is a project of EPA's Computational Toxicology P ...
  14 KB (2238 words) - 09:36, 17 September 2008
• QSAR
  ... at could have good inhibitory effects on specific [[targets]] and have low toxicity (non-specific activity). Of special interest is the prediction of [[partit ...
  6 KB (859 words) - 09:16, 20 August 2008
• DNA
  ... ouble helix. This inhibits both transcription and DNA replication, causing toxicity and mutations. As a result, DNA intercalators are often [[carcinogen]]s, a ...
  82 KB (11827 words) - 06:08, 20 August 2008
• Pharmacogenomics
  ... n]] or [[single-nucleotide polymorphism]]s with a drug's [[efficacy]] or [[toxicity]]. By doing so, pharmacogenomics aims to develop rational means to optimi ...
  2 KB (269 words) - 11:36, 20 August 2008
• Ampligen
  ... ommonly 400 mg) twice weekly for up to one year periods or greater. Animal toxicity studies support this observation in humans with primates demonstrating the ...
  20 KB (2874 words) - 11:26, 22 August 2008
• Cimetidine
  ... table [[nephrotoxicity]] and [[agranulocytosis]]. It was proposed that the toxicity arose from the [[thiourea]] group, and similar [[guanidine]]-analogues wer ...
  8 KB (1141 words) - 05:03, 25 August 2008
• Zidovudine
  ... o, with the certain toxicity of HIV infection outweighing the risk of drug toxicity. One of AZT's side effects includes [[anemia]], a common complaint in earl ... ... irin) and [[trimethoprim]], decrease the elimination rate and increase the toxicity.<!--
  16 KB (2364 words) - 06:44, 25 August 2008
• Malaria vaccine
  ... . Specific delivery systems can reduce this risk by limiting the potential toxicity and systemic distribution of newly developed adjuvants.
  26 KB (3922 words) - 11:25, 25 August 2008
• Biological Target
  ... . Specific delivery systems can reduce this risk by limiting the potential toxicity and systemic distribution of newly developed adjuvants.
  26 KB (3922 words) - 11:27, 25 August 2008
• Toxicogenomics
  ... Predicting Hazard, Characterizing Toxicity Pathways, and Prioritizing the Toxicity Testing of Environmental Chemicals at the [[United States Environmental Pr ...
  6 KB (772 words) - 04:56, 26 August 2008
• Metabonomics
  ... eliminated before it reaches [[clinical trial]]s on the grounds of adverse toxicity, it saves the enormous expense of the trials.
  25 KB (3638 words) - 04:58, 26 August 2008

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