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• Drug Discovery
  ... 7-8 years and large amount of money.For those engaged in drug design the research phase can be broken down into two main tasks: identification of new compou ... ... or phenotype of the disease. Understanding the disease mechanism directs research and formulates a possible treatment to slow or reverse the disease process ...
  23 KB (3467 words) - 03:48, 1 September 2008
• Virtual screening
  ... to related protein structures), and a docking code comprising an efficient searching algorithm and an accurate scoring function. ... crimination is not possible using a pharmacophore model, because available searching software cannot handle queries with the number of points needed to adeq ...
  5 KB (724 words) - 06:29, 11 August 2008
• Docking
  Docking can be divided into two separate problems. The search algorithm should create an optimum number of configurations that include t ... other modes explored through the searching algorithm.
  4 KB (593 words) - 04:42, 17 September 2008
• Homology Modeling
  ... with known structure is high enough (more than 25 or 30 %) simple database search programs like FASTA or [[BLAST]] are clearly adequate to detect the homolo ...
  9 KB (1291 words) - 11:19, 19 August 2008
• Comparative Immunity
  search for antibodies, T cells, and B cells in organisms
  1 KB (199 words) - 09:14, 11 August 2008
• 3D Pharmacophore
  ... organic molecule crystal structures. The software includes capabilities to search by geometric constraints as well as connection tables but (of course) does ... ... es prompted the development of 3D database software capable of storing and searching a large number of molecules. The 2D databases have continued largely as ...
  2 KB (295 words) - 07:10, 8 September 2008
• Immune System
  ... also attack cancer cells. The killer T cell has receptors that are used to search each cell that it meets. If a cell is infected, it is swiftly killed. Infe ... The B lymphocyte cell searches for antigen matching its receptors. If it finds such antigen it connects ...
  6 KB (969 words) - 11:17, 11 August 2008
• Zimelidine
  ... en working for the Swedish company Astra AB. It was discovered following a search for drugs with structures similar to brompheniramine (it is a derivative o ...
  2 KB (211 words) - 09:44, 11 August 2008
• Manual:Configuration settings
  * [[Manual:$wgSearchType|$wgSearchType]] - Type of DB search used. ... ont color="red">(deprecated)</font> - Set to true to use enhanced fulltext search.
  65 KB (8013 words) - 05:16, 13 September 2008
• Manual:FAQ
  var isDiff = (document.location.search && (document.location.search.indexOf("diff=") != -1 ||
  50 KB (7837 words) - 17:55, 8 September 2008
• Protein subcellular localization prediction
  ... This method combines power of composition based SVM models and similarity search techniques PSI-BLAST. <ref> J. Biol. Chem. 2005, 280:14427–14432. ... lization sites in gram-negative bacteria. Proteins. 11:95-110.</ref> Now researchers are also encouraged to use other PSORT programs such as WoLF PSORT and ...
  10 KB (1368 words) - 06:30, 20 August 2008
• Entrez
  ... werful [[federated search]] engine, or [[web portal]] that allows users to search many discrete [[health sciences]] databases at the [[National Center for B ... Entrez Global Query is an integrated search and retrieval system that provides access to all databases simultaneously ...
  5 KB (692 words) - 04:33, 17 August 2008
• Chemical file format
  ... a smiles string for each compound. eMolecules supports fast substructure searching based on parts of the molecular structure. #[[ChemExper]] is a commercial data base for molecular data. The search results include a two-dimensional structure diagram and a mole file for ma ...
  14 KB (2238 words) - 09:36, 17 September 2008
• Docking (molecular)
  ... program. The success of a docking program depends on two components: the [[search algorithm]] and the [[molecular mechanics|scoring function]]. === The search algorithm ===
  12 KB (1708 words) - 05:48, 17 September 2008
• Protein Structure Prediction
  ... either attempt to mimic protein folding or apply some stochastic method to search possible solutions (i.e., global optimization of a suitable energy functio ... ... d or experimental methods) make ab initio structure prediction an active research field.
  3 KB (489 words) - 06:17, 18 August 2008
• List of protein structure prediction software
  | Fragment assembly || Automated webserver || [http://bmm.cancerresearchuk.org/~3djigsaw/ server] | Consensus template search/fragment assembly || Webserver || [http://www.genesilico.pl/meta/ server]
  7 KB (907 words) - 11:34, 18 August 2008
• DNA
  ... ournal |author=Houdebine L |title=Transgenic animal models in biomedical research |journal=Methods Mol Biol |volume=360 |issue= |pages=163&ndash;202 |year= ... ... e identified by [[Gene prediction|gene finding]] algorithms, which allow researchers to predict the presence of particular [[gene product]]s in an organism ...
  82 KB (11827 words) - 06:08, 20 August 2008
• Protein Data Bank
  ... l 1999, when it was transferred to members of the [http://home.rcsb.org/ Research Collaboratory for Structural Bioinformatics (RCSB)]. [[Rutgers University] ... ... hindyalov IN, Bourne PE (2000). "The Protein Data Bank". ''Nucleic Acids Research'' '''28''':235-242. PMID 10592235
  11 KB (1705 words) - 05:34, 19 August 2008
• Bioinformatics Center, IMTECH
  ... ting more than 25,000 hits per day. BIC staff has published more than 60 research papers in reputed international journals, approximately 30 Copyright softw ... ==Research work==
  34 KB (4785 words) - 10:18, 19 August 2008
• BLAST
  ... in the [[Mus musculus|mouse]], a scientist will typically perform a BLAST search of the [[human genome]] to see if humans carry a similar gene; BLAST will ... ... sequences in a database search. BLAST is more time efficient than FASTA by searching only for the more significant patterns in the sequences, but with compa ...
  20 KB (3062 words) - 11:25, 19 August 2008

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