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- Drug Discovery ... ge of the DNA sequences of the human genome. Following an original founder mutation, these genetically inherited diseases run in families; examples include ph ... * The specific gene defects or mutations that bring about a hereditary disorder have been identified for a number ...23 KB (3467 words) - 03:48, 1 September 2008
- Target Identification ... on of disease gene is another approach for target identification.Because a mutation in gene leads to change in structure and function of protein .Disease gene ...3 KB (452 words) - 06:49, 11 August 2008
- DNA ... a thymine base, methylated cytosines are therefore particularly prone to [[mutation]]s.<ref>{{cite journal |author=Walsh C, Xu G |title=Cytosine methylation a ... {{further|[[Mutation]]}}82 KB (11827 words) - 06:08, 20 August 2008
- IMTECH ... ning steroidal agonists and a function based assay system for detection of mutation in a steroid receptor gene that impairs normal receptor function, were dev ...15 KB (2164 words) - 09:50, 19 August 2008
- FASTA format | Residue mutation13 KB (1766 words) - 11:08, 19 August 2008
- Zidovudine ... ]]'' (HAART). That is, it is combined with other drugs in order to prevent mutation of HIV into an AZT-resistant form.<!-- ... treatment HIV has the ability to gain an increased resistance to AZT by [[mutation]] of the [[reverse transcriptase]]. A study <!-- citation needed --> show ...16 KB (2364 words) - 06:44, 25 August 2008
- Simulated annealing ... roblem]], each state is typically defined as a particular ''tour'' (a [[permutation]] of the cities to be visited); and one could define the neighbours of a t ... ... iteria, similar to those used in SA, are used to select the candidates for mutation or combination, and for discarding excess solutions from the pool.22 KB (3441 words) - 08:51, 26 August 2008
- Protein design ... protein design algorithms use models of protein energetics to evaluate how mutations would affect a protein's structure and function. These [[Force field (ch ... ... free, open-source software package for protein design and prediction of [[mutation]] effects on [[protein folding]] stabilities and binding affinities. EGAD ...5 KB (750 words) - 09:27, 26 August 2008
- Pharmacodynamics ... her drugs. Disorders that affect pharmacodynamic responses include genetic mutations, thyrotoxicosis, malnutrition, myasthenia gravis, Parkinson's disease, an ... *Increased probability of cell [[Mutagen|mutation]] ([[carcinogen]]ic activity)8 KB (1104 words) - 17:10, 29 August 2008
- Cholera ... ained in humans due to a selective advantage: heterozygous carriers of the mutation (who are thus not affected by cystic fibrosis) are more resistant to V. ch ...11 KB (1694 words) - 04:22, 1 September 2008
- Drug resistance ... ]], but drugs have been developed principally against viral targets, and [[mutation]] rates among viruses still outpaces new development. One positive develop ...5 KB (674 words) - 10:32, 1 September 2008
- Cftr ... on channel that transports chloride ions across epithelial cell membranes. Mutations of the CFTR gene affect functioning of the chloride ion channels in these ... ... brane because it is degraded shortly after it is made. All disease-causing mutations in the CFTR gene prevent the channel from functioning properly, leading t ...4 KB (721 words) - 11:50, 4 September 2008
- Deadly diseases ... illion billion cell divisions, spontaneous errors in this process leads to mutations and ... ls have evolved an intricate mechanism to repair genetic damage. Thus if a mutation that transforms a cell into a cancerous one can be repaired before the cel ...11 KB (1745 words) - 03:42, 8 September 2008
- SNP Some used "mutation" to refer to variations with low allele frequency. ... e polypeptide sequence is termed ''synonymous'' (sometimes called a silent mutation) - if a different polypeptide sequence is produced they are ''nonsynonymou ...6 KB (930 words) - 08:53, 16 September 2008
- Site directed mutagenesis Site directed mutagenesis is a technique in which a mutation is created at a defined site in a DNA molecule. It requires: • A synthetic primer with the desired mutation at the desired site.12 KB (1824 words) - 05:04, 9 September 2008
- Phylogenetic analysis ... ion, it is impossible to determine whether one sequence bears an insertion mutation or the other carries a deletion. The problem is magnified in MSAs with una ... ... l sequences only when they have been corrected for the possibility of back mutations at individual sites. This correction is done through the use of a substit ...25 KB (3849 words) - 07:10, 9 September 2008
- HIV ... 32 mutation; these people are resistant to infection with R5 virus as the mutation stops HIV from binding to this coreceptor, reducing its ability to infect ... ... mely error-prone and it is during this step that mutations may occur. Such mutations may cause drug resistance. The reverse transcriptase then makes a complem ...42 KB (6578 words) - 18:15, 12 September 2008
- PAM Scoring Matrices PAM is Point Accepted Mutation. ... we expect 1% divergence or 1% of the amino acids to undergo accepted point mutations within the species of interest.6 KB (850 words) - 16:42, 16 September 2008
- PAM PAM is Point Accepted Mutation. ... we expect 1% divergence or 1% of the amino acids to undergo accepted point mutations within the species of interest.6 KB (850 words) - 10:43, 16 September 2008
- Artemisinin ... h Guiana in field isolates of malaria parasites has identified a different mutation in the calcium transporter (PfATP6) that is associated with resistance to ...14 KB (2074 words) - 05:03, 10 October 2008
