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- ADMET ... e administered in inactive form and is metabolised inside body into active metabolite. Majority of the drugs must pass through the liver which is Most drugs, particularly water-soluble drugs and their metabolites, are eliminated largely by the kidneys in urine. Some drugs are eliminate ...3 KB (515 words) - 12:01, 29 August 2008
- B Cells and T Cells ... at they specifically and rapidly respond to a small non-peptidic microbial metabolite, HMB-PP, an isopentenyl pyrophosphate precursor.15 KB (2456 words) - 10:44, 18 August 2008
- Pharmacogenetics ... t proceed by other pathways, one of which leads to the active thiopurine [[metabolite]] that is toxic to the bone marrow at high concentrations.7 KB (983 words) - 05:45, 21 August 2008
- Prodrug ... e prodrug is [[drug metabolism|metabolised]] [[in vivo]] into an '''active metabolite'''. The rationale behind the use of a prodrug is generally for absorption, ... ... ] (Invega) is an atypical antipsychotic for schizophrenia. It's the active metabolite of [[risperidone]] (Risperdal).5 KB (640 words) - 06:41, 25 August 2008
- Metabonomics ... 5-28, April 25, 2005</ref> The metabolome represents the collection of all metabolites in a biological organism, which are the end products of its gene expressi ... ... first draft of the human metabolome. They catalogued approximately 2500 [[metabolite]]s, 1200 [[drug]]s and 3500 food components that can be found in the human ...25 KB (3638 words) - 04:58, 26 August 2008
- Abacavir ... lic acid metabolite, 36% 5'-glucuronide metabolite, 15% unidentified minor metabolites). Fecal (16%)7 KB (1000 words) - 03:50, 27 August 2008
- Medicines of Comman use ... conjugation (94%), and about 4% is metabolized by CYP-450 oxidase to toxic metabolite. ... 100% is recovered in the urine within the first day, primarily as inactive metabolites. 5% is excreted as unchanged drug.18 KB (2902 words) - 15:23, 29 August 2008
- Capsaicin ... related compounds are called capsaicinoids and are produced as a secondary metabolite by chili peppers, probably as deterrents against herbivores. Pure capsaici ...14 KB (2280 words) - 03:49, 4 September 2008
- Analysis of Metabolic ‘Choke’ and ‘Load’ points as Drug Targets in Pathogenic Bacteria ... d could be seen in the case of the citrate cycle where most of the enzymes/metabolites have high load values.3 KB (480 words) - 12:38, 27 September 2008
- Sulfasalazine ... o side-effects such as agranulocytosis and hypospermia. However, the other metabolite of sulfasalazine, 5-aminosalicylic acid (5-ASA) is attributed to the drug' ... Sulfasalazine, and its metabolite 5-ASA, are poorly absorbed. Its main mode of action is therefore believed ...8 KB (1198 words) - 04:07, 17 October 2008
- Androgen ... lone; commonly called stanolone[citation needed]) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, teste ...7 KB (1027 words) - 07:00, 17 October 2008
- Nordazepam ... However, it is used primarily in the treatment of anxiety. It is an active metabolite of diazepam, chlordiazepoxide, clorazepate, prazepam, and medazepam.1 KB (174 words) - 08:20, 17 October 2008
- Glutathione ... yl-''p''-benzoquinone imine (NAPQI), the reactive cytochrome P450-reactive metabolite formed by paracetamol (or acetaminophen as it is known in the US), that be ...6 KB (856 words) - 04:41, 24 October 2008
- Estradiol ... strogens such as [[estrone]] and [[estriol]]. Estriol is the major urinary metabolite. Estradiol is conjugated in the liver by sulfate and glucuronide formation ... ... o mammalian sex differentiation is that estradiol is one of the two active metabolites of testosterone in males (the other being [[dihydrotestosterone]]), and s ...21 KB (2912 words) - 05:26, 24 February 2009
- Androstanolone(DHT) A potent androgenic metabolite of TESTOSTERONE. Dihydrotestosterone (DHT) is generated by a 5-alpha reduc ...8 KB (1212 words) - 08:30, 24 October 2008
- Cortisone ... . Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726). ... ] activity than cortisone and thus cortisone can be considered an inactive metabolite of cortisol. However 11-beta-steroid dehydrogenase can catalyze the rever ...5 KB (727 words) - 07:14, 20 February 2009
- Testosterone ... tion and termination of growth. This occurs indirectly via [[estradiol]] [[metabolites]] and hence more gradually in men than women. ... ibits the conversion of testosterone into [[dihydrotestosterone]] (DHT), a metabolite which is more potent than testosterone. By lowering the levels of dihydro ...35 KB (5048 words) - 06:11, 4 March 2009
- Estriol A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, an ...4 KB (502 words) - 05:37, 24 February 2009
- 17-Hydroxyprogesterone ... oduced during the synthesis of [[glucocorticoid]]s and [[sex steroid]]s. A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves ...7 KB (940 words) - 07:06, 31 October 2008
- Aldosterone * by increase in the plasma concentration of Angiotensin III, a metabolite of Angiotensin II.17 KB (2332 words) - 11:48, 19 February 2009
