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- Cimetidine ... -cyano-2-methyl-3-[2-[(5-methyl-1''H''-imidazol-4-yl) methylsulfanyl]ethyl]guanidine ... roposed that the toxicity arose from the [[thiourea]] group, and similar [[guanidine]]-analogues were investigated until the ultimate discovery of cimetidine.8 KB (1141 words) - 05:03, 25 August 2008