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  • Drug Discovery
    o Proteins and enzymes ... subtypes is important, counterscreens might include a panel of homologous enzymes, different protein complexes, or heterooligomers. Counterscreens profile t ...
    23 KB (3467 words) - 03:48, 1 September 2008
  • Target Identification
    #Proteins and enzymes
    3 KB (452 words) - 06:49, 11 August 2008
  • Comparative Immunity
    Among these agents are enzymes that digest microbial cell
    1 KB (199 words) - 09:14, 11 August 2008
  • Ticrynafen
    ... rug metabolism. Unfortunately, the metabolic reaction carried out by these enzymes converted tienilic acid to a thiophene sulfoxide which proved highly elect ...
    1 KB (204 words) - 09:43, 11 August 2008
  • Drug targets
    * enzymes ===Enzymes===
    7 KB (1041 words) - 05:38, 17 September 2008
  • Enzyme
    ... tabolic pathways by either accerlating or inhibiting a particular reaction.Enzymes behaves like catalyst but there is some inportant difference is that enzym ...
    336 B (48 words) - 06:09, 18 August 2008
  • DNA
    ... nurev.biochem.70.1.369 <!--Retrieved from PMID by DOI bot-->}}</ref> These enzymes are also needed to relieve the twisting stresses introduced into DNA stran ... ... cell to replicate chromosome ends using the enzyme [[telomerase]], as the enzymes that normally replicate DNA cannot copy the extreme 3′ ends of chromosom ...
    82 KB (11827 words) - 06:08, 20 August 2008
  • Synthetic biology
    ... was awarded to Arber, Nathans and Smith for the discovery of restriction enzymes, Waclaw Szybalski wrote in an editorial comment in the journal Gene: ''Th ...
    17 KB (2568 words) - 06:47, 17 September 2008
  • Systems biology
    ... ns give rise to the function and behavior of that system (for example, the enzymes and metabolites in a metabolic pathway).
    18 KB (2525 words) - 05:00, 12 September 2008
  • BioBrick
    ... s between the two parts are removed, allowing the use of those restriction enzymes without breaking the new, larger BioBrick apart. [4]. To facilitate this a ...
    4 KB (618 words) - 10:20, 19 August 2008
  • RNA
    ... ]]s called [[RNA polymerase]]s and is generally further processed by other enzymes. RNA is central to the synthesis of [[protein]]s. Here, a type of RNA call ... ... o proteins. In this fashion, RNAs can achieve chemical [[catalysis]], like enzymes.<ref>{{cite journal | author=Higgs PG| title=RNA secondary structure: ph ...
    31 KB (4467 words) - 07:24, 20 August 2008
  • Proteomics
    ... effects to its function. For example, during [[cell signalling]] many [[enzymes]] and structural proteins can undergo [[phosphorylation]]. The addition o ... ... ]] is a small peptide that can be affixed to certain protein substrates by enzymes called [[E3 ubiquitin ligase]]s. Determining which proteins are poly-ub ...
    16 KB (2303 words) - 09:50, 17 September 2008
  • Pharmacogenetics
    ... nvolved in adverse drug reactions were also those that were metabolized by enzymes with known polymorphisms (see Phillips, 2001). ... um chloride <ref>Gardiner SJ, Begg EJ. Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacol Rev. 2006; 58:521-90</ref>. As a consequ ...
    7 KB (983 words) - 05:45, 21 August 2008
  • Zidovudine
    ... ffusion]] and thereby also to cross the [[blood-brain barrier]]. Cellular enzymes convert AZT into the effective 5'-triphosphate form. Studies have shown th ...
    16 KB (2364 words) - 06:44, 25 August 2008
  • Metabonomics
    ... AA1363. <ref>Saghatelian A. et al. "Assignment of endogenous substrates to enzymes by global metabolite profiling." Biochemistry. 2004 Nov 16;43(45):14332-9. ...
    25 KB (3638 words) - 04:58, 26 August 2008
  • HB plot
    ... ''' are [[xenobiotic]]-metabolizing [[membrane]]-bound [[heme]]-containing enzymes that use molecular [[oxygen]] and electrons from [[NADPH cytochrome P450 r ...
    8 KB (1156 words) - 09:51, 17 September 2008
  • Nonribosomal peptide
    ... one [[operon]] in bacteria and in [[gene cluster]]s in [[eukaryote]]s. The enzymes are organized in modules that are responsible for the introduction of one ... ... ]], [[acylation]], [[halogenation]], or [[hydroxylation]]. The responsible enzymes are usually associated to the synthetase complex and their genes are organ ...
    9 KB (1134 words) - 09:44, 17 September 2008
  • Drug interaction
    ... ct drug responses in the clinic }}</ref> Further, human drug-metabolizing enzymes are typically activated through engagement of [[nuclear receptor]]s.<ref n ...
    5 KB (686 words) - 10:34, 28 August 2008
  • Drug discovery hit to lead
    *not interfere with the [[P450]] enzymes nor with the [[P-glycoproteins]]
    4 KB (541 words) - 06:08, 17 September 2008
  • Chemicals with harmful effects
    ... oride channel antagonist, and a Ca2+, Mg2+ ATPase inhibitor. Both of these enzymes are involved in the transfer of nerve impulses. Symptoms of acute poisonin ...
    41 KB (6328 words) - 05:37, 2 September 2008

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