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  • Targeted Drug Delivery
    ... drug delivery''' is the most important goal of pharmaceutical research and development. Drug delivery is the method or process of administering a pharmaceutical compound ...
    4 KB (602 words) - 13:27, 5 November 2011
  • Drug Discovery
    ... in drug design the research phase can be broken down into two main tasks: identification of new compounds showing some activity against a target biologi ... We represent here the process of drug discovery and development in a flow diagram ...
    23 KB (3467 words) - 03:48, 1 September 2008
  • Screening
    ... ess of identifying the molecule that can act as drug molecule.This process depends upon the availability and chemical synthesis of compounds.
    311 B (44 words) - 06:23, 18 August 2008
  • Virtual screening
    ... isticated, and, hence, can usefully exploit different types of information describing the receptor. ... a model built by homology to related protein structures), and a docking code comprising an efficient searching algorithm and an accurate scoring functi ...
    5 KB (724 words) - 06:29, 11 August 2008
  • High Throughput Screening
    471 B (75 words) - 05:54, 21 August 2008
  • Combinatorial Chemistry
    ... nsive ways of screening such large numbers of compounds. Consequently they developed robotics and automated methods to help them with these screenings. ... ... a technology for creating molecules en masse and testing them rapidly for desirable properties-continues to branch out rapidly. Compared with conventio ...
    5 KB (795 words) - 05:10, 9 September 2008
  • Target Validation
    ... is directly involved in a disease process and can be a suitable target for development of a new therapeutic drug.Pharmaceutical industry experts and ana ...
    865 B (117 words) - 17:29, 4 August 2008
  • Homology Modeling
    ... structure from the amino acid sequence.This is also known as Comparative modeling.This process in based on the selection of templete molecule whose 3D s ... ... Like other methods of structure prediction, current practice in homology modeling is assessed in a biannual large-scale experiment known as the Critical ...
    9 KB (1291 words) - 11:19, 19 August 2008
  • Tuberculosis
    M tuberculosis continues to kill millions of people yearly worldwide. * In 1995, 3 million deaths from TB occurred.
    7 KB (965 words) - 17:55, 30 September 2008
  • Autoimmunity
    ... rmones, the gluco-corticoides. when dampening mechanism fail or are overridden, a response directed against self-antigen can occur, resulting in autoimm ... ... rug antigens that results in inappropriate tissue damage, may also be considered an autoimmune like disease.
    2 KB (363 words) - 07:01, 11 August 2008
  • Descriptive Toxicology
    ==Defintion== * Increase in cancer incidence
    2 KB (221 words) - 10:03, 11 August 2008
  • Phenformin and Buformin
    ... in''' is an anti-diabetic drug from the biguanide class. It is no longer widely available because it is known to induce lactic acidosis. Like metformin, phenformin leads to weight loss, something often desirable in type 2 diabetics, and it is for this reason that there is still ...
    528 B (85 words) - 09:43, 11 August 2008
  • Alpidem (Ananxyl)
    ... more well known sleeping medication zolpidem. Unlike zolpidem however, alpidem does not produce sedative effects at normal doses, and is instead used sp ... ... tructure of alpidem is not related to that of the benzodiazepines, and alpidem is thus sometimes referred to as a nonbenzodiazepine.
    2 KB (227 words) - 07:18, 18 August 2008
  • Fen-phen
    ... gs: fenfluramine and phentermine. Fenfluramine, and later, a related drug, dexfenfluramine, was marketed by American Home Products, now known as Wyeth. ... eart disease and pulmonary hypertension, primarily in women who had been undergoing treatment with Fen-phen, the Food and Drug Administration (FDA) requ ...
    3 KB (420 words) - 09:54, 11 August 2008
  • Cerivastatin
    ... as withdrawn from the market in 2001 because of the high rate of serious side-effects. ... at of the other statins. Cerivastatin also induced myopathy in a dose-dependent manner when administrated as monotherapy, but that was revealed only aft ...
    2 KB (224 words) - 09:57, 11 August 2008
  • Protein subcellular localization prediction
    ... ein function and [[genome project|genome annotation]], and it can aid the identification of drug targets. ... iate [[subcellular localization|subcellular compartment]] to perform their desired function.
    10 KB (1368 words) - 06:30, 20 August 2008
  • High-throughput screening
    ... lts of these experiments provide starting points for drug design and for understanding the interaction or role of a particular biochemical process in bi ... ... biochemical or biological mechanism. Typical HTS screening libraries or "decks" can contain from 100,000 to more than 2,000,000 compounds (circa 2008) ...
    7 KB (1110 words) - 15:17, 14 August 2008
  • Virtual high throughput screening
    ... ation: A medicinal chemistry perspective | journal = Curr Opin Drug Discov Devel | volume = 11 | issue = 4 | pages = 559-68 | year = 2008 | month = July ... ... ls. A candidate ligand can then be compared to the pharmacophore model to determine whether it is compatible with it and therefore likely to bind.<ref ...
    4 KB (504 words) - 08:35, 17 September 2008
  • Docking (molecular)
    In the field of [[molecular modeling]], '''docking''' is a method which predicts the preferred orientation ... ... biological and [[pharmaceutical]] significance of molecular docking, considerable efforts have been directed towards improving the methods used to pred ...
    12 KB (1708 words) - 05:48, 17 September 2008
  • Antibody
    ... ur polypeptides– two heavy chains and two light chains linked by disulphide bonds to form a "Y" shaped molecule. ... an cleave this region, producing Fab or fragment antigen binding that include the variable ends of an antibody. Material used for the studies shown belo ...
    9 KB (1437 words) - 11:39, 18 August 2008

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