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- Pharmacogenetics ... CYP450s affect large populations. One member of the CYP450 superfamily, [[CYP2D6]], now has over 75 known allelic variations, some of which lead to no acti ...7 KB (983 words) - 05:45, 21 August 2008
- Cimetidine ... P450]] enzyme system (specifically [[CYP1A2]], [[CYP2C9]], [[CYP2C19]], [[CYP2D6]], [[CYP2E1]], and [[CYP3A4]]). This inhibition forms the basis of the num ...8 KB (1141 words) - 05:03, 25 August 2008
- Prodrug * [[Codeine]] is demethylated by the liver enzyme [[CYP2D6]] to the active [[morphine]], as well as several other compounds that may ...5 KB (640 words) - 06:41, 25 August 2008
- Progestrone ... drug molecules. The microsomal, membrane-associated, P450 isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, and CYP1A2 are responsible for the oxidative met ...8 KB (1073 words) - 09:35, 19 February 2009
- Codeine ... ary enzyme occupancy, (560x0.75) putting the ceiling limit at 420mg. Total CYP2D6 saturation or exceeding the ceiling dose often results in excessive histam ... ... metabolizers"; multiple copies of the gene for 2D6 produce high levels of CYP2D6 and will metabolize drugs through that pathway more quickly than others.23 KB (3399 words) - 04:10, 29 April 2009
