From DrugPedia: A Wikipedia for Drug discovery

Rv2460c
Name
ATP-dependent Clp protease proteolytic subunit
Identifiers
Swiss Prot	P63783
Genbank	888174
PDB	?
Chemical data
Formula	C19H25NO [1]
Mol. wt.	23509 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	4.75

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

[edit] General

CLEAVES PEPTIDES IN VARIOUS PROTEINS IN A PROCESS THAT REQUIRES ATP HYDROLYSIS. CLP MAY BE RESPONSIBLE FOR A FAIRLY GENERAL AND CENTRAL HOUSEKEEPING FUNCTION RATHER THAN FOR THE DEGRADATION OF SPECIFIC SUBSTRATES.

Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website

[edit] Protein Sequence

>Rv2460c, TB.seq 2762532:2763173 MW:23509 MNSQNSQIQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPG GGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLSGVIQGQFSDLEIQAAEIERM RTLMETTLARHTGKDAGVIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTA

[edit] Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q16740.1	44	67	190	1e-42
sp|Q14416.2	28	45	84	0.021
sp|P54136.2	28	39	184	0.69
sp|Q0ZGT2.1	41	68	29	2.2
sp|Q8TEK3.2	34	49	85	3.3

[edit] Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
Integral Membrane

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [7]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

[edit] External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.