Protein tailless homolog;Tll;mTll
From DrugPedia: A Wikipedia for Drug discovery
Contents |
[edit] Source Organism
Mus musculus (Mouse).
[edit] Taxomomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
[edit] Subcellular Localization
Nucleus (By similarity).
[edit] Developmental Stage
Expression is first detected on 8 dpc and increases until 13.5 dpc, then sharply decreases from day 13 dpc until 18 dpc. Expression is barely detected in newborn brains but increases again after birth.
[edit] Similarity
Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.
[edit] Post translational Modification
[edit] Function
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. Tlx-/-mice show central nervous system cortical defects (reduction in the size of rhinencephalic and limbic structures of the brain, including the olfactory, infrarhinal and entorhinal cortex, amygdala, and dentate gyrus) and progressive retinal and optic nerve degradation with associated blindness.
