Porphyromonas gingivalis
From DrugPedia: A Wikipedia for Drug discovery
Porphyromonas gingivalis
It is a non-motile, gram-negative, rod-shaped, anaerobic pathogenic bacterium and forms black colonies on blood agar.
| Kingdom | Bacteria |
|---|---|
| Phylum | Bacteroidetes |
| Class | Bacteroidia |
| Order | Bacteroidales |
| Family | Porphyromonadaceae |
| Genus | Porphyromonas |
| Species | P. gingivalis |
| Binomial | Porphyromonas gingivalis |
[edit] Pathogenic Activity
It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as the upper gastrointestinal tract, respiratory tract, and in the colon. Collagen degradation that is observed in Chronic Periodontal Disease results in part from the collagenase enzymes of this species. It has also been linked to Rheumatoid Arthritis. Porphyromonas gingivalis contains the PAD (Peptidyl-Arginine Deaminase) which is involved in citrullination. Patients with Rheumatoid Arthritis have an increased incidence of periodontal disease and antibodies to the bacterium are significantly more common in patients with Rheumatoid Arthritis.
