PolysacDB Y O-polysaccharide 2270
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Y O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Shigella flexneri
[edit] Basic Structure
The O-LPS consists of a tetrasaccharide repeating unit α-L-Rhap-(1-->2)-α-L-Rhap(1-->3)- . This tetrasaccharide is polymerized and joined by β-1,2 linkages between N-acetyl-D-glucosamine and L-rhamnosyl to form the O-polysaccharide chain
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
heat-killed S. flexnerf bacteria serotype Y
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Antisera
[edit] Antibody type and class
N/A
[edit] Assay System
ELISA, FARR assay
[edit] Cross-reactivity
The polyclonal rabbit anti-group antigen 3.4 antibodies reacted with the lb, 2a, 3b, 4a. 4b, and Y LPS. They did not bind to1a and 5a. In glycoconjugate ELISA's it bound to all saccharides especially abcd- and decasaccharide- BSA antigens
[edit] Proposed epitopes
Antigen 3,4 seemed to be the epitope
[edit] Proposed Utility
This Mab would help in the delineation of the antigenic stucture of Y O polysaccharide
