PolysacDB Type V capsular polysaccharide 2413
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Type V capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Streptococcus Group B
[edit] Basic Structure
The native type v polysaccharide contains D-glucose, D-galactose, 2-acetamido-2-deoxy-glucose and sialic acid in a molar ratio of 3:2:1:1. It consists of a repeating backbone of -->4)-α-D-Glcp-(1-->4)-α-D-Galp-(1-->4)-β-D-Glcp-(1--> with branching at 6th and 3rd positions
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Antisera
[edit] Antibody type and class
N/A
[edit] Assay System
ELISA, Ouchterlony diffusion
[edit] Cross-reactivity
Antibodies against the typeV capsuled o not cross-reactw ith other GBS capsular types and appear to recognize an epitope which is not as heavily dependent on the presenceo f the terminal side chain sialic acid residues as that of the type Ia, 11, and I11 GBS polysaccharides
[edit] Proposed epitopes
β-D-Gal-(1-->4)-β-D-GlcNAc segmenot of the trisaccharide side chain, which is present in the core but not in the backbone polysaccharide, also contributes to the native epitope. The residues of the linear backbone and/or the glucopyranosyl side chain also form part of the antibody-binding epitope
[edit] Proposed Utility
This antisera helped in the determination of immunodominant epitopes in Type V polysaccharide in group B Streptococcus
