PolysacDB Type 5 Capsular polysaccharide 2372
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Type 5 Capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Staphylococcus aureus
[edit] Basic Structure
Type 5 capsular polysaccharide consists of following residues : -4)-β-D-ManpNAcA3Ac-(1-->4)-α-L-FucpNAc-(1-->3)-β-D-FucpNAc-(1-
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Formalinized cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 17-23
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA and Bacterial agglutination assays
[edit] Cross-reactivity
This Mab reacted with each of four different type 5 S. aureus clinical isolates but with none of the five S. aureus clinical isolates possessing type 8 capsular polysaccharides. This Mab was also completely unreactive with S. aureus strains possessing capsular types 1, 2, 6, and 7, but was reactive with type 4 strain
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab will be used in various studies of S. aureus capsular polysaccharides. In particular, the use of these antibodies should facilitate the biochemical purification and further characterization of these polysaccharides. In addition, these reagents can be used to investigate the role of capsular polysaccharides in the invasiveness and virulence of encapsulated strains of S. aureus. Knowledge gained from these studies will be applicable to the development of a suitable vaccine. These antibodies will also be evaluated as diagnostic reagents for use in staphylococcal disease
