PolysacDB Type 1b polysaccharide 2410

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Contents

[edit] Carbohydrate Name

Type 1b polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Streptococcus Group B

[edit] Basic Structure

N/A


[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

a mixture composed of equal parts of the vaccine suspensions of strains H36B (type Tb), 18RS21 (type II), and 1073 (nontypeable)

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab SMB19

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, indirect immunofluorescence

[edit] Cross-reactivity

This Mab reacted specifically with the sialylated form of the type 1b polysaccharide. This Mab cross-reacts with some oligosaccharides in human milk and certain fetal antigens

[edit] Proposed epitopes

sialyllacto-N-tetraose residues seemed to be the immunodominant epitope

[edit] Proposed Utility

This Mab will help in the development of appropriate vaccines against GBS that would include the possibility of inducing major cross-reactions with human glycoconjugates

[edit] Weblink

PubMed

[edit] External Links