PolysacDB Phenolic glycolipid antigen 1633
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Phenolic glycolipid antigen
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium leprae
[edit] Basic Structure
It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
[edit] Proposed functions
It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
[edit] Antigenic Nature used to produce antibodies
Partially purified phenolic glycolipid from M. leprae
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab A1E
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, TLC autoradiography and immunofluorescence
[edit] Cross-reactivity
This Mab was specific to M. leprae glycolipid but cross-reacted with Mycobacterium terrae. Mycobacterium nonchromogenicum and Mycobacterium fortuitium
[edit] Proposed epitopes
Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
[edit] Proposed Utility
This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
