PolysacDB Phenolic glycolipid-I 1732
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Phenolic glycolipid-I
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium leprae
[edit] Basic Structure
Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose
[edit] Proposed functions
It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 1-25
[edit] Antibody type and class
N/A
[edit] Assay System
Inhibitory ELISA
[edit] Cross-reactivity
This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy
