PolysacDB Phenolic glycolipid-I 1729
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Phenolic glycolipid-I
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium leprae
[edit] Basic Structure
Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose
[edit] Proposed functions
It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy
[edit] Antigenic Nature used to produce antibodies
Phenolic glycolipid-1 and heat-killed M. leprae
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab VI703
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA
[edit] Cross-reactivity
This Mab reacted with deacylated Phenolic glycolipid-1[ PGL-I (PGL-I OH )], but did not bind to PGL antigens from M. kansasii (mycoside A), M. bovis (deacylated mycosideB), and M. tuberculosis (PGL-Tb OH )
[edit] Proposed epitopes
The outer monosaccharide, disaccharide and the trisaccharide all contributed to the epitope recognized by this Mab
[edit] Proposed Utility
This Mab was used for the development of peptide mimotopes resembling the carbohydrate structures recognized by this Mab
