PolysacDB O-polysaccharide 2323
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Shigella flexneri
[edit] Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Heat killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Antisera
[edit] Antibody type and class
N/A
[edit] Assay System
ELISA
[edit] Cross-reactivity
The highest titers seen were against serotype 3a and 3b LPSs
[edit] Proposed epitopes
In S. flexneri serotype 3a and 3b LPSs there is no structural feature to which the type III antigen epitope can be assigned. Instead, the serotype specificity is a consequence of the addition of two group antigen epitopes to the basic structure in serotype 3a (7,8 and 6 epitopes) and of one group antigen epitope to the basic structure in serotype 3b (6 epitope). The α-D-glucose-(1-->3)-α-L-rhamnose was assigned as the determinant for group 7,8 antigen, and the 2-O-acetyl-α-L-rhamnose III structure was assigned as the determinant for group 6 antigen
[edit] Proposed Utility
N/A
