PolysacDB O-polysaccharide 2041
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Pseudomonas aeruginosa O5
[edit] Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Formalin killed whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MF15-4
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, immunoblotting, ouchterlony immunodiffusion
[edit] Cross-reactivity
This Mab was specific to serotype O5
[edit] Proposed epitopes
The epitope consisted of N-acetyl fucosamine residues with an αglycosidic linkage and a minimum of six O repeats of serotype O5 polysaccharide
[edit] Proposed Utility
This Mab helps us shed some light on the nature of O-specific and common epitopes in the LPS of P. aeruginosa
