PolysacDB O-polysaccharide 1237
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
O-polysaccharide
[edit] Carbohydrate Class
O-polysaccharide [LPS]
[edit] Source Microbe
Brucella melitensis
[edit] Basic Structure
O-polysaccharide consists of an unbranched linear homopolymer of 10 to 100 α-1,2-linked 4-formamido-4,6-dideoxy-D-mannose (N formylperosamine) residues. The O-polysaccharide is covalently linked to a core oligosaccharide
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Whole B. melitensis Cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 16C10
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA
[edit] Cross-reactivity
This antibody did not cross-react with S-LPSs of S. urbana, Vibrio cholerae and E. coli O:157, but cross-reacted with S-LPS of Y. enterocolitica O:9 along with Brucella A and M dominant strains. Reactivity was more towards M dominant strains
[edit] Proposed epitopes
This Mab was directed against the C/Y epitope which basically consists of 4 α1,2-linked D-Rha4NFo residues
[edit] Proposed Utility
This Mab helped in the epitope strucure elucidation
