PolysacDB N-propionylated group B meningococcal polysaccharide 1794
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
N-propionylated group B meningococcal polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Neisseria meningitidis
[edit] Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
[edit] Proposed functions
It is an important virulence factor
[edit] Antigenic Nature used to produce antibodies
Glycoconjugates
[edit] Carrier Name
Tetanus toxoid
[edit] Conjugation Method
N-propionylated group B meningococcal polysaccharide was combined with freshly purified monomeric tetanus toxoid in a solution of phosphate buffer containing NaBH3CN and incubated at 37C for 5 days
[edit] Antibodies
Mab 12C5
[edit] Antibody type and class
IgG2b
[edit] Assay System
ELISA, bactericidal assays
[edit] Cross-reactivity
N/A
[edit] Proposed epitopes
The epitope was located only on extended helical segments of the polysaccharide
[edit] Proposed Utility
This Mab had bactericidal activity
