PolysacDB N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide 1611
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Group B Neisseria meningitidis
[edit] Basic Structure
It is a homopolymer of α(2-->8) sialic acid
[edit] Proposed functions
This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 735D4
[edit] Antibody type and class
IgG2a
[edit] Assay System
ELISA, Immunoelectrophoresis and immunodiffusion
[edit] Cross-reactivity
This Mab reacted with with all E. coli K1 and group B meningococcal strains tested but did not react with E. coli strains having capsular types K12, K13, K14, and K92; and group A and C meningococci
[edit] Proposed epitopes
The epitope was proposed to consist of repeating α(2-->8)-linked Neu5Ac units
[edit] Proposed Utility
This antibody is an important addition to the analyticaln tools available for the study of the structure and function of the E. coli K1 and meningococcal B capsules
