PolysacDB N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide 1610
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
N-propionyl substituted Neisseria meningitidis group B capsular polysaccharide
[edit] Carbohydrate Class
Capsular polysaccharide
[edit] Source Microbe
Group B Neisseria meningitidis
[edit] Basic Structure
It is a homopolymer of α(2-->8) sialic acid
[edit] Proposed functions
This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins
[edit] Antigenic Nature used to produce antibodies
a patient suffering from IgM lambda monoclonal gammopathy
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab NOV
[edit] Antibody type and class
IgM
[edit] Assay System
Ouchterlony Gel Diffusion, ELISA, invivo protection assays
[edit] Cross-reactivity
This Mab reacted with group B meningococcal and E. coli K1 capsular polysaccharides and did not react with a(2 --> 9)-linked poly-N-acetylneuraminic acid, the capsular polysaccharide of the group C meningococcus, nor with the capsular polysaccharide of E. coli K92 or K100. It also crossreacts with polynucleotides and denatured DNA
[edit] Proposed epitopes
The epitope was proposed to consist of α(2-->8)-linked poly-N-acetylneuraminic acid
[edit] Proposed Utility
This Mab is protective against E. coli in newborn rats
