PolysacDB Lipopolysaccharide 2314
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Shigella flexneri serotype 2b
[edit] Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Heat killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab MASF(7,8)-l
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA, agglutination tests
[edit] Cross-reactivity
This Mab showed excellent specificity for the 7,8 antigenic determinant [S. flexneri serotypes 2b, 3a, 5b, and X]
[edit] Proposed epitopes
This Mab apparently interact with the α-D-glucose p(1-->4)-α-L-rhamnosyl pIII epitope
[edit] Proposed Utility
This Mab can be used for detection and identification of shigella flexneri species
