PolysacDB Lipopolysaccharide 2207
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Salmonella enteritidis
[edit] Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Tyvp-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Heat killed Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 178H11
[edit] Antibody type and class
IgA
[edit] Assay System
ELISA and immunoblotting
[edit] Cross-reactivity
This Mab recognized O:9 antigen of subserogroup OD1 LPS as well as LPS from S. enteritidis
[edit] Proposed epitopes
This Mab is directed to O:9 antigen of the LPS
[edit] Proposed Utility
This Mab agglutinated all Salmonella OD1 strains and all S. enteritidis clinical isolates
