PolysacDB Lipopolysaccharide 2183
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Serogroup C1 (0:6,7) Salmonella
[edit] Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-β-D-Manp-(1-->2)-α-D-Manp [branched to α-D-Glcp-(1-->3)] -(1-->2)-α-D-Manp-(1-->2)-α-D-Manp-(1-->3)-β-D-GlcpNAc-(1-
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Whole cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Cl-2
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA, slide agglutination test
[edit] Cross-reactivity
This Mab reacted strongly with all strains of serogroup C1 Salmonella that have either O:6(1),7, O:6(2),7, or O:6(1,2),7 antigens and also reacted with the phage-14 lysogenized C1 strains that bear the phage-modified O antigen (O:6,7----O:6,7,14)
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab can be used for the diagnosis of serogroup C1 salmonella
