PolysacDB Lipopolysaccharide 1529

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Klebsiella pneumoniae O1:K2

[edit] Basic Structure

N/A

[edit] Proposed functions

CPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection

[edit] Antigenic Nature used to produce antibodies

LPS-associated proteins plus LPS

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 6D5

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA

[edit] Cross-reactivity

This Mab did not cross-react with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4

[edit] Proposed epitopes

This Mab recognized the LPS core

[edit] Proposed Utility

This Mab showed invivo protection in mice against LPS induced homologous shock

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database