PolysacDB Lipopolysaccharide 1455
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Haemophilus ducreyi
[edit] Basic Structure
It consist of an oligosaccharide core ketosidically linked via a 3-deoxy-D-manno-octulosonic acid (Kdo) residue to the lipid A region. The oligosaccharide core characteristic of these bacteria has been divided into two regions: (i) an inner core, consisting of three L-glycero-D-manno-heptose (Hep) residues and one phosphorylated Kdo residue, and (ii) an outer core, with one or more heterogeneous oligosaccharide branches containing mainly galactose (Gal) and glucose (Glc) residues
[edit] Proposed functions
LPS plays an important role in the infection process
[edit] Antigenic Nature used to produce antibodies
total membrane preparation of H. ducreyi
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab DP8
[edit] Antibody type and class
IgG1
[edit] Assay System
whole-cell enzyme immunoassay (Enzyme Immunoassay) and colony dot immunoblotting
[edit] Cross-reactivity
This Mab cross-reacted with 50 strains of H. ducreyi but not with any other bacteria tested
[edit] Proposed epitopes
phosphate groups seemed to be an important part of the epitope. The epitope consists of Glcβ1-->4Hepα1-->Kdo(P) that is linked via 1-->3 linkage to Hepα1-->2Hep
[edit] Proposed Utility
This Mab would help to detect the organism in environmental samples and clinical specimens
