PolysacDB Lipopolysaccharide 1358
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Chlamydia trachomatis serotype E
[edit] Basic Structure
The LPS is composed of the pentasaccharide bisphosphate αKdo-(2-8)-αKdo-(2-->4)-αKdo-(2-6)-βGlcN-4P-(1-->6) αGlcN-1P (Kdo is 3-deoxy-α-d-manno-oct-2-ulosonic acid)
[edit] Proposed functions
LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
[edit] Antigenic Nature used to produce antibodies
elementary bodies of Chlamydia trachomatis serotype E
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab EV1-H1
[edit] Antibody type and class
IgG2a
[edit] Assay System
IFT assay, ELISA
[edit] Cross-reactivity
This antibody cross-reacted with Salmonella Minnesota LPS and Chlamydia psittaci
[edit] Proposed epitopes
The epitope cosisted of a trisaccharide of a-3-deoxy-D-manno-2-octulosonic acid (KDO)
[edit] Proposed Utility
This Mab can be used in the epitope characterization of Chlamydial LPS
