PolysacDB Lipopolysaccharide 1163
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Bordetella pertusis
[edit] Basic Structure
B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B
[edit] Proposed functions
The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
[edit] Antigenic Nature used to produce antibodies
Whole cells of Bordetella Pertusis
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab HBp2
[edit] Antibody type and class
IgM
[edit] Assay System
Dot enzyme Immunoassay, Immunoblotting
[edit] Cross-reactivity
This antibody reacted with all B. pertusis strains. also cross-reacted with a clinical isolate of B. bronchiseptica. No cross-reaction was observed against B. parapertussis and other gram-negative species
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
Mab HBp2 showed high lytic capability against B. pertussis
