PolysacDB Lipopolysaccharide 1069

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Escherichia coli C600

[edit] Basic Structure

N/A

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

whole formalinized E. coli C600 cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 786

[edit] Antibody type and class

IgG3

[edit] Assay System

ELISA and immunoblotting

[edit] Cross-reactivity

This antibody cross-reacted with LPS core types K-12, R4, and R2 but did not cross-react with Rl LPS and R3 LPS,

[edit] Proposed epitopes

The epitope was proposed to consist of trisaccharide sequence Hexp(1->2)-α-D -Glcp(1->3)α-D-Glcp->(Hepp) at the inner region of the outer core, in which the heptose-distal glucose is immunodominant

[edit] Proposed Utility

This Mab may be used for the detection of LPS core structures but also for analysis of the molecular forms resolved on polyacrylamide gels (banding patterns)

[edit] Weblink

[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC261975 &tool=pmcentrez&rendertype=abstract PubMed Central]

[edit] External Links

• Link to PolysacDB database