PolysacDB Lipoologosaccharide band A of the LPS 1175
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipoologosaccharide band A of the LPS
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Bordetella pertusis 9340
[edit] Basic Structure
B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B
[edit] Proposed functions
The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
[edit] Antigenic Nature used to produce antibodies
N-Lauroyl sarcosine membrane extract (SME) from B. pertussis 9340
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab BL-5
[edit] Antibody type and class
IgG1
[edit] Assay System
ELISA,immunoblotting, Antibody accessibility radioimmunoassay, bactericidal asaay, competitive ELISA
[edit] Cross-reactivity
This antibody reacted with all B.pertusis strains, did not react with B. parapertusis or other gram negative bacteria but cross-reacted with 4 B. bronchiseptica strains which had LOS AB phenotype
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab was capable of inducing bactericidal activity in uitro.
