PolysacDB Lipoarabinomannan 1036
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipoarabinomannan
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Mycobacterium leprae
[edit] Basic Structure
Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
[edit] Proposed functions
T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
[edit] Antigenic Nature used to produce antibodies
whole killed mycobacteria leprae cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Cs-35
[edit] Antibody type and class
IgM
[edit] Assay System
Indirect and Competitive ELISA
[edit] Cross-reactivity
This antibody cross-reacted to M. tuberculosis and other Mycobacterium speices.
[edit] Proposed epitopes
β-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans
[edit] Proposed Utility
These antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria.
